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high score indicate that the cancer is aggressive and is likely to metastasize without treatment.
Staging
One of the most important factors to consider in the management of prostate cancer is the stage. The most commonly used staging system is the Whitmore-Jewett system, which defines four stages with accompanying substages:
Stage A
Undetectable tumor confined to the prostate gland; usually an incidental finding during prostate gland biopsy.
A1. Tumor presents a low Gleason score and is well differentiated.
A2. Tumor presents a higher Gleason score, is moderately or poorly differentiated, and possesses a capacity for metastatic activity.
Stage B
Palpable tumor (or nonpalpable but indicated by high PSA count) confined to the prostate gland.
B1. Focalized palpable tumor confined to one lobe of the prostate gland.
B2. Palpable tumor involving both lobes of the prostate gland.
Stage C
A tumor localized to the periprostatic area but extending through the prostatic capsule; seminal vesicles may be involved.
C1. Clinical evidence of extracapsular extension.
C2. Extracapsular tumor producing bladder or urethral obstruction.
Stage D
Metastatic prostate cancer.

 
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