Oral EDTA - A Food Additive with Many Remarkable Properties

This article first appeared in the
September 1997
issue of VRP's Nutritional News

by Ward Dean, M.D.

In the previous issue of Nutritional News, intravenous EDTA chelation therapy was discussed. This issue continues with a discussion of EDTA's protective and enhancing effects as a food additive on foods and food supplements, as well as some clinically tested uses of oral EDTA.

The Food and Drug Administration has approved the synthetic amino acid, ethylene diamine tetraacetic acid (EDTA), as a pharmaceutical agent for the treatment of lead and other heavy metal poisoning or exposure. In older literature, the FDA also approved intravenous EDTA treatment as "possibly effective in occlusive vascular disorders ... arrhythmias and atrioventricular induction defects ... and in the treatment of pathologic conditions to which calcium tissue deposits or hypercalcemia may contribute other than those listed above."1 These "possibly effective" indications were removed from FDA-approved literature in the late 1970's for reasons known only to the FDA. Fortunately, physicians are not limited solely to FDA-approved indications and may prescribe approved drugs for whatever "unapproved" conditions they find them to be effective. Consequently, since EDTA is approved for the treatment of heavy metal poisoning (especially lead), many physicians continue to use pharmaceutical EDTA with great benefit in many diseases and conditions other than their officially approved uses. There are two medical associations whose physician members are trained in the administration of EDTA for the treatment and prevention of atherosclerosis and other chronic degenerative diseases. These organizations are the American College

for Advancement in Medicine (800-532-3688) and the Great Lakes Association of Clinical Medicine (800-286-6013). Members of these organizations and their patients find that EDTA chelation therapy is highly effective as an alternative or addition to more traditional / widely accepted approaches such as angioplasty or bypass surgery.

Beneficial Uses of Oral EDTA in Cardiovascular Disease
In addition to the controversial but widespread recognition of EDTA's intravenous benefits, is its less well-known clinical uses when administered orally. Early clinical studies with EDTA reported loss of fat in rats, reduction of cholesterol in rabbits, and reduced blood pressure in humans. Consequently, a study of the effects of oral EDTA on patients with atherosclerosis and/or hypertension was conducted on 10 patients. Four of these patients had hypertension, four had angina pectoris, one had peripheral vascular disease (intermittent claudication), and one was recovering from a heart attack. All were treated with 1 gm of oral EDTA daily for 3 months. Seven of the ten patients experienced significant reductions in their cholesterol levels, and blood pressure was reduced in all ten. The most marked change occurred in the patient with intermittent claudication, whose cholesterol dropped from 278 mg per 100 ml to 128! This patient also reported improved exercise tolerance, and the researchers found improved pulsations in the extremities. The four patients with angina pectoris also all reported improvement.2

In another series of 20 patients who suffered from hypercholesterolemia, hypertension, angina or peripheral vascular disease, one gram of EDTA was administered orally every day for 3 months. During that short time, elevated cholesterol levels in nine of the patients dropped to within the normal range. No adverse results were experienced by any of the patients. Angina attacks were reduced in frequency and severity in five individuals. One person who previously had suffered a heart attack and experienced several angina attacks daily thereafter, obtained complete relief.3

In another study, two patients with extremely elevated cholesterol were treated with oral EDTA. One patient took EDTA in progressively increasing doses ranging from 500 mg to 4 gm daily for one year, and the other took 1,000 mg daily for three years (Fig 1). Although the first patient suffered a heart attack after three years of therapy, she recovered uneventfully, and had reduced angina pains and improved sense of well-being with continued use of EDTA. The second patient - in addition to hypercholesterolemia - had a condition known as xanthomatosis (yellowish papules in the skin, related to elevated blood lipids). She not only experienced dramatic reductions in her cholesterol levels with oral EDTA treatment, but her skin lesions completely resolved.4 Other laboratory studies (including kidney and liver function) remained normal throughout the study for both patients. This is further confirmation of the safety of oral EDTA, considering that doses as high as 4 gm daily were consumed.

Further support of the anti-atherosclerotic effects of oral EDTA are provided by Italian researchers who found that two grams of oral EDTA daily were effective in reducing blood cholesterol.5 Scientists at Wayne State University quantified reversal in atherosclerotic plaque in rabbits that were treated with daily subcu-taneous EDTA injections.6

EDTA's Multiple Uses as a Food Additive
In addition to its remarkable pharmaceutical uses, the FDA has also approved EDTA as a food additive that is generally recognized as safe (GRAS). EDTA's array of biochemical properties make it extremely valuable as a food additive. It has the ability to: (1) bind with many metals; (2) act synergistically with other antioxidants to stabilize fats and oils; (3) prevent discoloration of potato products; (4) stabilize vitamins; (5) prevent discoloration of fish and shellfish; (6) prevent flavor changes in milk; (7) inhibit the thickening of stored condensed milk; (8) enhance the foaming properties of reconstituted skim milk; (9) prevent color changes of scrambled eggs prepared from egg powder; (10) preserve canned legumes; (11) prevent gushing in beer; (12) promote flavor retention and delay loss of carbonation in soft drinks; (13) prevent oxidation of meat products; and (14) prevent discoloration of canned fruits and vegetables.7, 8 In fact, EDTA's use in foods is so widespread that its presence in bloody evidence even created questions during the O.J. Simpson trial as to its source-i.e., from food or from blood previously drawn as evidence - since EDTA is also used as an anticoagulant in blood used for laboratory studies.

Absorption of Oral EDTA

In 1954, Dr. Harry Foreman and his colleagues performed a landmark study to determine how much orally administered EDTA the body absorbs.9 The scientists found that the body absorbs a maximum of 5 per cent of orally consumed EDTA (Fig. 2) and that it can take up to three days for the EDTA to be totally excreted. If someone consumed nutritional supplements that contained 800 mg of EDTA (used as a stabilizer of the ingredients in the supplement), then we can assume from Dr. Foreman's research that about 40 mg will be absorbed each day and that 1,200 mg will be absorbed each month. That equates to almost the same amount of EDTA administered in one intravenous chelation treatment using the low-dose optimum protocol of Drs. Born and Geurkink10 that was described in last month's Nutritional News.

Consequently, those unable to obtain intravenous chelation therapy due to financial, occupational, geographical or other restraints, or who wish to undergo a less-intensive preventive approach may be able to obtain many of the same benefits of intravenous chelation therapy by consuming food-additive EDTA that is used as a stabilizer in food supplements. Because of concern that long-term use of EDTA might result in depletion of certain elements, Drs. Ira Manville and Robin Moser recommended that a potent vitamin and mineral formula be administered during treatment with EDTA.11 (This should be taken with meals and not with the EDTA formula.) Dr. Garry Gordon agrees and also recommends that because EDTA binds to nutritional as well as to unwanted metallic elements, it is most effective when taken on an empty stomach.12 (1 hr before or 2-3 hours after a meal.) WD

References:

1.	Calcium disodium edetate and disodium edetate. Federal Register, Volume 35, No. 8, Tuesday, January 13, 1970, 585-587.
2.	Perry, H. Mitchell, Schroeder, Henry A. Depression of cholesterol levels in human plasma following ethylenediamine tetracetate and hydralazine. J Chronic Diseases, 1955, 2: 5, 520-532.
3.	Schroeder, Henry A. A practical method for the reduction of plasma cholesterol in man. J Chronic Diseases, 1956, 4: 461-468.
4.	Perry, Jr., and Camel, G., Some effects of CaNa2EDTA on plasma cholesterol and urinary zinc in man, in: Metal Binding in Medicine, by Marvin J. Seven and L. Audrey Johnson (eds), 1960, J.B. Lippincott Company, Philadelphia, 209-215.
5.	Mariani, B., Bisetti, A., and Romeo, V. Blood-cholesterol-lowering action of the sodium salt of calciumethylenediaminotetraacetic acid. Gazz Intern Med e Chir, 1957. 62: 1812-1823.
6.	Wartman, A., Lampe, T.L., McCann, D.S., and Boyle, A.J. Plaque reversal with MgEDTA in experimental atherosclerosis: Elastin and collagen metabolism. J Atherosclerosis Res, 1967, 7: 331-341.
7.	Aamoth, H.L., and Butt, F.J. Maintaining food quality with chelating agents. Annals New York Academy of Sciences, 1960, 526-531.
8.	Furia, T. EDTA in Foods-A Technical Review. Food Technology, 1964, 18: 12, 1874-1882.
9.	Foreman, H., Trujillo, T. The metabolism of C14 labeled ethylenediaminetetra-acetic acid in human beings. J Lab Clin Med, 1954, 43: 566-571.
10.	Born, G.R., and Geurkink, T.L. Improved peripheral vascular function with low dose intravenous ethylene diamine tetraacetic acid (EDTA). Townsend Letter for Doctors. July, 1994, # 132, 722-726.
11.	Manville, I., and Moser, R. Recent developments in the care of workers exposed to lead. AMA Arch Indust Health, 1955, 12: 528-538.
12.	Gordon, G. Oral Chelation with EDTA. J Holistic Medicine, 1986, 8: 1 & 2, 79-80.