64     Little as physicians have hitherto been in the habit of observing accurately, the aggravation that so certainly follows such palliative treatment could not altogether escape their notice. A striking example of this is to be found in J. H. Schulze's Diss. qua corporis humani momentanearum alterationum specimina quœdam expenduntur, Halæ, 1741, §28. Willis bears testimony to something similar (Pharm. rat., §7, cap. i, p. 298): "Opiata dolores atroscissimos plerumque sedant atque indolentiam—procurant, eamque—aliquamdiu et pro stato quodam tempore continuant, quo spatio elapso dolores mox recrusescunt et brevi ad solitam ferociam augentur." And also at page 295: "Exactis opii viribus illico redeunt tormina, nec atrocitatem suam remittunt, nisi dum ab eodem pharmaco rursus incantuntur." In like manner J. Hunter (On the Venereal Disease, p. 13) says that wine and cordials given to the weak increase the action without giving real strength, and the powers of the body are afterwards sunk proportionally as they have been raised, by which nothing can be gained, but a great deal may be lost.