20     What good results have ever ensued from those fœtid artificial ulcers, so much in vogue, called issues? If even during the first week or two, whilst they still cause pain, they appear somewhat to check by antagonism a chronic disease, yet by and by, when the body has become accustomed to the pain, they have no other effect than that of weakening the patient and giving stil1 greater scope to the chronic affection. Or does anyone imagine, in this nineteenth century, that they serve as an outlet for the escape of the materia peccans? It almost appears as if this were the case!