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Immunoelectrophoresis - serum

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Contents of this page:

Illustrations

Blood test
Blood test

Alternative Names    Return to top

IEP - serum; Immunoglobulin electrophoresis - serum; Gammaglobulin electrophoresis; Serum immunoglobulin electrophoresis

Definition    Return to top

Serum immunoelectrophoresis is a test that tells whether or not you have immunoglobulins in the blood. Immunoglobulins are proteins that make antibodies. The proteins can be abnormal. There are various types of immunoglobulins. If you do have these proteins, this test can also help identify what specific type they are.

How the Test is Performed    Return to top

Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic. An elastic band is placed around the upper arm to apply pressure and cause the vein to swell with blood.

A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the band is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.

In infants or young children, the area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. A bandage may be applied to the puncture site if there is any bleeding.

How the Test Will Feel    Return to top

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the Test is Performed    Return to top

This test is performed to assess the clonality (monoclonal or polyclonal) of immunoglobulins.

    Return to top

No monoclonal antibodies are detected.

What Abnormal Results Mean    Return to top

In some malignant disorders (that is, multiple myeloma, chronic lymphocytic leukemia) a single clone of lymphocytes produces one type of protein -- a monoclonal immunoglobulin. This is identifiable as monoclonal (all the same type) by immunoelectrophoresis. Some people have monoclonal immunoglobulins, but do not have a malignant disorder.

Risks    Return to top

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

References    Return to top

McPherson RA and Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. Philadelphia, Pa: WB Saunders; 2007.

Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 4th ed. Philadelphia, Pa: Churchill Livingston; 2005.

Update Date: 4/1/2007

Updated by: Mark Levin, MD, Hematologist and Oncologist, Newark, NJ. Review provided by VeriMed Healthcare Network.

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