Ceruloplasmin is a test that measures the amount of ceruloplasmin (a copper-containing protein) in blood serum.

Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic. An elastic band is placed around the upper arm to apply pressure and cause the vein to swell with blood.

A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the band is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.

In infants or young children, the area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. A bandage may be applied to the puncture site if there is any bleeding.

No fasting or other preparation is usually needed.

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

This test may be performed when disorders of copper metabolism or storage are suspected. Ceruloplasmin is the major copper-containing protein in plasma.

Lower-than-normal ceruloplasmin levels may indicate:

• Menkes' syndrome (Menkes' kinky hair syndrome) -- very rare
• Wilson's copper storage disease (rare)

• Pregnancy
• Lymphoma
• Acute and chronic infections
• Rheumatoid arthritis

• Excessive bleeding
• Fainting or feeling light-headed
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)
• Multiple punctures to locate veins

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.