Small bowel tissue biopsy smear is a laboratory test which examines tissue from the small intestine for the presence of microorganisms associated with certain intestinal infections.

The specimen is obtained by EGD (esophagogastroduodenoscopy), a flexible scope that is passed through the digestive tract to the small intestine to view the organs and obtain specimens.

A sample of small intestinal tissue is biopsied (removed). The specimen is placed on a microscope slide, stained, and sectioned (sliced) for histological (tissue) examination.

The preparation is the same as for an EGD.

The test will feel the same as an EGD.

The test is performed to diagnose an infection or parasitic infestation of the small bowel. In most cases, this test is only done when stool examinations and duodenal string test have been unable to confirm the diagnosis.

The small intestine contains certain bacteria and yeast which are considered normal intestinal flora. The presence of pathogenic bacteria or certain parasites is abnormal.

The presence of certain microorganisms, such as Giardia, Entamoeba, and others is abnormal.

The risks are the same as for an EGD with biopsy.

Examination of tissue by a pathologist is another valuable aid in the diagnosis of certain intestinal infections.