despondence (n.) Look up despondence at Dictionary.com
1670s, from Latin despondere "to give up, lose, lose heart, resign, to promise in marriage" (especially in phrase animam despondere, literally "give up one's soul"), from the sense of a promise to give something away, from de- "away" (see de-) + spondere "to promise" (see spondee). A condition more severe than despair.