mole (n.1) Look up mole at Dictionary.com
spot on skin, Old English mal "spot, mark, blemish," especially on cloth or linen, from Proto-Germanic *mailan "spot, mark" (source also of Old High German meil, German Mal, Gothic mail "wrinkle"), from PIE root *mai- "to stain, defile" (source also of Greek miainein "to stain, defile," see miasma). Specifically of dark marks on human skin from late 14c.
mole (n.2) Look up mole at Dictionary.com
type of small burrowing mammal (Talpa europea), mid-14c., probably from obsolete moldwarp, literally "earth-thrower." Spy sense first recorded 1974 in John le Carré (but suggested from early 20c.), from notion of "burrowing." Metaphoric use for "one who works in darkness" is from c. 1600.
mole (n.3) Look up mole at Dictionary.com
"breakwater," 1540s, from Middle French môle "breakwater" (16c.), ultimately from Latin moles "mass, massive structure, barrier," from PIE root *mo- "to exert oneself" (source also of Greek molos "effort," molis "hardly, scarcely;" German mühen "to tire," müde "weary, tired;" Russian majat' "to fatigue, exhaust," maja "hard work").
mole (n.4) Look up mole at Dictionary.com
unit of molecular quantity, 1902, from German Mol coined 1900 by German chemist Wilhelm Ostwald (1853-1912), short for Molekül (see molecule).