ukulele (n.) Look up ukulele at Dictionary.com
1896, from Hawaiian 'ukulele, literally "leaping flea," from 'uku "louse, flea" + lele "to fly, jump, leap." Noted earlier in English as the Hawaiian word for "flea." The instrument so called from the rapid motion of the fingers in playing it. It developed from a Portuguese instrument introduced to the islands c. 1879.