"relating to knowledge," especially mystical or esoteric knowledge of spiritual things, 1650s, from Greek gnōstikos "knowing, good at knowing, able to discern," from gnōstos "known, perceived, understood," earlier gnōtos, from gignōskein "learn to know, come to know, perceive; discern, distinguish; observe, form a judgment," from PIE *gi-gno-sko-, reduplicated and suffixed form of root *gno- "to know."