"cultural and geographical region of inland Eastern U.S.," 1880s, from the Appalachian Mountains, which are its core. Earlier Appalachia was proposed as a better name for "United States of America" by Washington Irving in 1839 (though he preferred Alleghenia) and this may have been the coinage of the word (see America).
apotheosis
apotheosize
apothesis
apotropaic
app
Appalachia
Appalachian
appall
appalled
appalling
Appaloosa