"stricken by malignant forces (natural or supernatural), cursed, blighted," 1550s, from blast (v.), with the notion of "balefully breathed upon." In the sense of "cursed, damned" it is a euphemism attested from 1680s. Meaning "drunk or stoned" dates from 1972, perhaps from the condition of one so affected, but blast (v.) "smoke marijuana" is attested from 1959.