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commerce (n.)

1530s, "social intercourse;" 1580s, "interchange of goods or property, trade," especially trade on a large scale by transportation between countries or different parts of the same country, from Middle French commerce (14c.), from Latin commercium "trade, trafficking," from com "with, together" (see com-) + merx (genitive mercis) "merchandise" (see market (n.)). It also was the name of a card game very popular in 1770s and '80s. As a verb, "have dealings with," 1590s. Related: Commerced, commercing.

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Definitions of commerce from WordNet
1
commerce (n.)
transactions (sales and purchases) having the objective of supplying commodities (goods and services);
commerce (n.)
social exchange, especially of opinions, attitudes, etc.;
2
Commerce (n.)
the United States federal department that promotes and administers domestic and foreign trade (including management of the census and the patent office); created in 1913;
Synonyms: Department of Commerce / Commerce Department / DoC
From wordnet.princeton.edu