as an intensive execration, "odious, detestable, damned," 1650s, past-participle adjective from confound in its older sense of "condemn, curse," which came to be considered "a milder form of imprecation" [OED]. It is perhaps a euphemism for damned. The sense of "put to mental confusion" is recorded from mid-14c.
a cloudy and confounded philosopher
conformation
conformism
conformist
conformity
confound
confounded
confraternity
confrere
confront
confrontation
confrontational