"liable to be wearied," 1650s, from defatigate (v.), 1550s, from Latin defatigatus, past participle of defatigare "to weary, tire out, exhaust with labor," from de "utterly, down, away" (see de-) + fatigare "to weary" (see fatigue (n.)). Also see indefatigable.
defalcate
defalcation
defamation
defamatory
defame
defatigable
default
defaulter
defeasance
defeat
defeatism