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demented (adj.)

"having lost the normal use of reason, afflicted with dementia," 1640s, from obsolete dement "drive mad." Related: Dementedness.

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Definitions of demented from WordNet

demented (adj.)
affected with madness or insanity;
Synonyms: brainsick / crazy / disturbed / mad / sick / unbalanced / unhinged
From wordnet.princeton.edu