disadvantage (n.)

late 14c., disavauntage, "loss, injury, prejudice to interest," from Old French desavantage (13c.), from des- "not, opposite of" (see dis-) + avantage "advantage, profit, superiority" (see advantage). Meaning "that which prevents success or renders it difficult" is from 1520s.

"hinder, do something disadvantageous to," 1530s, from disadvantage (n.). Related: Disadvantaged; disadvantaging.