"to upset, embarrass," 1834, discombobricate, American English, fanciful mock-Latin coinage of a type popular then. Compare, on a similar pattern, confusticate (1852), absquatulate (1840), spifflicate "confound, beat" (1850), scrumplicate "eat" (1890). Related: discombobulating; discombobulation.
discobolus
discography
discolor
discoloration
discolour
discombobulate
discombobulated
discomfit
discomfiture
discomfort
disconcert