1530s "unfavorable regard, slight displeasure;" 1580s, "state of being regarded unfavorably;" see dis- "the opposite of" + favor (n.). As a verb, "withdraw or withhold favor or support," from 1560s. Related: Disfavored; disfavoring.
he is in disfavor with the king
disentangle
disenthrall
disequilibrium
disestablish
disesteem
disfavor
disfavour
disfigure
disfigurement
disfranchise
disfunction