1817, "composed of two parts, double, twofold," from Latin duplex "twofold," from duo "two" (from PIE root *dwo- "two") + -plex, from PIE root *plek- "to plait." The noun in the sense of "house or other building so divided that it forms two dwelling places" (also sometimes "two-story apartment") is American English, by 1922.
a duplex transaction
duplex system
duplex telephony
duodecimo
duodenal
duodenary
duodenum
dupe
duplex
duplicate
duplication
duplicative
duplicitous
duplicity