exacerbation (n.)

"act of exacerbating; state of being exacerbated; increase of violence or virulence, aggravation," c. 1400, exacerbacioun, from Late Latin exacerbationem (nominative exacerbatio), noun of action from past-participle stem of Latin exacerbare "exasperate, irritate, provoke," from ex, here probably "thoroughly" (see ex-), + acerbus "harsh, bitter," from acer "sharp, keen," from PIE root *ak- "be sharp, rise (out) to a point, pierce." Oldest use in English is Biblical, in reference to the Provocation in the Wilderness.