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folio (n.)

mid-15c., from Late Latin folio "leaf or sheet of paper," from Latin folio, ablative of folium "leaf" (source also of Italian foglia, French feuille, Spanish hoja), from PIE *bhol-yo- "leaf" (source also of Greek phyllon "leaf," Gaelic bile "leaflet, blossom"), suffixed form of root *bhel- (3) "to thrive, bloom." Ablative of location, because this was used in page references. Meaning "volume of the largest size" first attested 1620s.

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Definitions of folio from WordNet

folio (n.)
the system of numbering pages;
Synonyms: pagination / page number / paging
folio (n.)
a sheet of any written or printed material (especially in a manuscript or book);
Synonyms: leaf
folio (n.)
a book (or manuscript) consisting of large sheets of paper folded in the middle to make two leaves or four pages;
the first folio of Shakespeare's plays
From wordnet.princeton.edu