mid-14c., "bear fruit," from Old French fructifiier "bear fruit, grow, develop" (12c.), from Late Latin fructificare "bear fruit," from Latin fructus "fruit, crops; profit, enjoyment" (from PIE root *bhrug- "to enjoy," with derivatives referring to agricultural products) + combining form of facere "to make, do" (from PIE root *dhe- "to set, put"). Transitive use from 1580s. Related: Fructified; fructifying; fructification.