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frustrate (v.)

mid-15c., from Latin frustratus, past participle of frustrari "to deceive, disappoint, make vain," from frustra (adv.) "in vain, in error," which is related to fraus "injury, harm," a word of uncertain origin (see fraud). Related: Frustrated; frustrating.

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Definitions of frustrate from WordNet

frustrate (v.)
hinder or prevent (the efforts, plans, or desires) of;
What ultimately frustrated every challenger was Ruth's amazing September surge
Synonyms: thwart / queer / spoil / scotch / foil / cross / baffle / bilk
frustrate (v.)
treat cruelly;
Synonyms: torment / rag / bedevil / crucify / dun
From wordnet.princeton.edu