"steep slope of a road or railroad," 1835, principally in American English, probably from grade (n.) by analogy of quotient, etc. [OED]. It was used 17c. as an adjective, of animals, "characterized by walking;" in that case it is probably from Latin gradientem, present participle of gradi "to walk."
a five-degree gradient
gradation
gradational
grade
grader
Gradgrind
gradient
gradual
gradualism
gradually
graduand
graduate