1876, from German Grübelsucht, psychiatric term for "a form of obsession in which even the simplest facts are compulsively queried" [OED], from grübeln "to brood" (see grub (v.)) + sucht "mania."
growth
groyne
grub
grubber
grubby
grubelsucht
grub-stake
Grub-street
grudge
gruel
gruelling