late 14c., "one who handles" anything, agent noun from handle (v.). Specific sense of "one engaged in trade" is from 1690s; that of "prizefighter's assistant" (1916) was earlier used in reference to dogfights and cockfights (1825).
the senator's campaign handlers
handiwork
hand-jive
handkerchief
handle
handlebar
handler
handling
hand-loom
hand-made
handmaid
hand-me-down