1590s, "spun at home," from home (n.) + spun. Figurative sense of "plain, homely" is from c. 1600. As a noun, "homemade cloth or clothing," from c. 1600.
a sweater knitted of nubbly homespun yarns
the air of homespun country boys
homespun linen
homespun garments
Homeric
homeroom
homeschool
homesick
homesickness
homespun
homestead
hometown
homeward
homework
homey