1773, "too inconsiderable to matter;" 1787, "that cannot be sufficiently appreciated," from in- (1) "not, opposite of" + appreciable. Perhaps modeled on French inappreciable. Related: Inappreciably.
inappreciable fluctuations in temperature
inanition
inanity
inappetence
inapplicable
inapposite
inappreciable
inapprehensible
inappropriate
inapt
inaptitude
inarticulate