"breeding of animals from the same parentage," c. 1842, from in + verbal noun from breed (v.). The older term for "to breed from animals of the same parentage" was to breed in and in (1765). The verb inbreed is attested from 1590s in the sense "produce within" (intransitive).
inboard
inborn
inbound
inbox
inbred
inbreeding
Inc.
Inca
incalculable
incandescence
incandescent