late 14c., "weak, unsound" (of things), from Latin infirmus "weak, frail, feeble, not strong or firm" (figuratively "superstitious, pusillanimous, inconstant"), from in- "not, opposite of" (see in- (1)) + firmus "strong; stable," figuratively "constant, trusty" (from suffixed form of PIE root *dher- "to hold firmly, support" ). Of persons, "not strong, unhealthy," first recorded c. 1600. As a noun from 1711.