"unlucky, luckless," late 14c., from Latin infortunatus, from in- "not, opposite of" (see in- (1)) + fortunatus "prospered, prosperous; lucky, happy" (see fortunate (adj.)). Also used in medieval astrology in reference to the supposed malevolent influence of certain positions or combinations of planets. The word lies beneath the "obsolete" headstone in OED. Related: infortune (n.); infortunacy.