early 15c., in medicine, "a making cold, cooling; a state of coolness," from Late Latin infrigidationem (nominative infrigidatio) "a cooling," noun of action from past participle stem of infrigidare "to make cold," from in- "in, into" (from PIE root *en "in") + frigidare, from frigidus "cold" (see frigid). A verb infrigidate is attested from 1540s.
infra-red
infrasonic
infrastructure
infrequency
infrequent
infrigidation
infringe
infringement
infundibulum
infuriate
infuriating