1580s, "state of being insane, seriously impaired state of mental functioning," from Latin insanitatem (nominative insanitas) "unhealthfulness, unsoundness, disease," noun of quality from insanus "mad, insane; outrageous, excessive" (see insane). Meaning "extreme folly" is from 1844. The Latin abstract noun was insania ""unsoundness of mind, madness, frenzy."
inquisitor
inro
inroad
insalubrious
insane
insanity
insatiability
insatiable
insatiate
inscribe
inscription