1754, "incapability of dissolving in a liquid," 1791, from Late Latin insolubilitas, from Latin insolubilis "that cannot be loosened" (see insoluble). Earlier in a sense "that cannot be dissolved" (of marriage), 1610s. The meaning "that cannot be solved" (1722) probably is a separate formation from insoluble.
insolate
insolation
insole
insolence
insolent
insolubility
insoluble
insolvable
insolvency
insolvent
insomnia