"intolerable, not to be endured," early 15c., from in- (1) "not, opposite of" + sufferable. Related: Insufferably.
insufferable insolence
the insufferable heat of August in a New York apartment with no air conditioning
insubordinate
insubordination
insubstantial
insubstantiality
insue
insufferable
insufficiency
insufficient
insufflation
insula
insular