1783, "intermeddling," from interfere on model of difference, etc. In physics, in reference to the mutual action of waves on each other, from 1802, coined in this sense by English scientist Dr. Thomas Young (1773-1829). Telephoning (later broadcasting) sense is from 1887. In chess from 1913; in U.S. football from 1894.
he ran interference for the quarterback
interesting
interface
interfacial
interfaith
interfere
interference
interferometer
interferon
interflow
interfold
intergalactic