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interstate (adj.)

1838, American English, in reference to traffic in slaves, from inter- "between" + state (n.) in the U.S. sense. Interstate commerce is that carried on by persons in one U.S. state with persons in another. Noun sense of "an interstate highway" is attested by 1975, American English.

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Definitions of interstate from WordNet
1
interstate (n.)
one of the system of highways linking major cities in the 48 contiguous states of the United States;
Synonyms: interstate highway
2
interstate (adj.)
involving and relating to the mutual relations of states especially of the United States;
interstate commerce
interstate highways
From wordnet.princeton.edu