1540s, of animals, "process of bringing forth young in a single birth," verbal noun from present participle of litter (v.). Meaning "act of furnishing with bedding" is from c. 1600. That of "act of dropping disordered waste matter" is from 1900.
litotes
litre
litter
litterateur
litterbug
littering
little
littleness
littlish
littoral
liturgical