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malaise (n.)

c. 1300, maleise "pain, suffering; sorrow, anxiety," also, by late 14c., "disease, sickness," from Old French malaise "difficulty, suffering, hardship," literally "ill-ease," from mal "bad" (see mal-) + aise "ease" (see ease (n.)). The current use, in the sense of "unease, discomfort," especially "an indefinite feeling of uneasiness," is perhaps a mid-18c. reborrowing from Modern French. A Middle English verbal form, malasen "to trouble, distress" (mid-15c.), from Old French malaisier, did not endure.

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Definitions of malaise from WordNet

malaise (n.)
physical discomfort (as mild sickness or depression);
Synonyms: unease / uneasiness
From wordnet.princeton.edu