c. 1600, "affected with mania, raving with madness," from French maniaque (14c.), from Late Latin maniacus, from Greek maniakos, from mania (see mania). Borrowed at first in French form. From 1727 as "pertaining to mania." The noun, "one who is affected with mania, a madman," is attested by 1763, from the adjective.
man-hater
Manhattan
manhole
manhood
mania
maniac
maniacal
manic
Manichaean
Manichaeism
manicotti