"book, paper, or other document written by hand with ink, pencil, etc.," as distinguished from anything printed, especially one written before the use of printing, c. 1600, earlier as an adjective, "written with the hand, handwritten, not printed" (1590s ), from Medieval Latin manuscriptum "document written by hand," from Latin manu scriptus "written by hand," from manu, ablative of manus "hand" (from PIE root *man- (2) "hand") + scriptus (neuter scriptum), past participle of scribere "to write" (from PIE root *skribh- "to cut"). The abbreviation is MS, plural MSS. Related: Manuscriptal.