"given to meddling, apt to interpose in the affairs of others," 1610s, from meddle + -some (1). Earlier was medlous "quarrelsome, meddlesome" (mid-15c.). Related: Meddlesomely; meddlesomeness. "Meddlesome Matty" is the title of a piece by Ann Taylor in "Original Poems for Infant Minds" (1806) about a little girl who, by meddling, breaks her grandmother's eye-glasses and gets a face-full of grandma's snuff.
Matilda, smarting with the pain,
And tingling still, and sore,
Made many a promise to refrain
From meddling evermore;
And 'tis a fact as I have heard.
She ever since has kept her word.
The book, which also included "Twinkle, Twinkle, Little Star" by Ann's sister Jane, was very popular in its day.