"person afflicted with melancholy, one who is affected with mental gloom," 1819, from melancholia. Earlier in same sense were melancholian (1630s), melancholist (1590s), melancholic (1580s).
meiosis
meistersinger
Mekong
*mel-
melancholia
melancholiac
melancholic
melancholy
Melanesia
melange
Melanie