1878 in the physiology sense of "the sum of the chemical changes within the body by which the protoplasm is renewed, changed, or prepared for excretion," from French métabolisme, from Greek metabole "a change," from metaballein "to change," from meta "change" (see meta-) + ballein "to throw" (from PIE root *gwele- "to throw, reach"). The word also has been used in theology, poetics, and entomology.