"the middle; an interior or central part, point, or position," c. 1400, from Middle English middes (mid-14c.), from mid (adj.) + adverbial genitive -s. The unetymological -t is perhaps on model of superlatives (compare against).
in the midst of the crowd
midpoint
Midrash
midriff
midsection
midshipman
midst
midstream
midsummer
midterm
midtown
midway