late 14c., mortificacioun, "mortifying of the flesh, act of subduing the passions and appetites, suppression of bodily desires," from Late Latin mortificationem (nominative mortificatio) "a killing, putting to death," from past-participle stem of mortificare (see mortify). Meaning "death of one part of the body while the rest is still alive" is from early 15c. Sense of "feeling of humiliation" is recorded by 1640s.