"to make untidy, put in a state of disorder," 1837, American English, probably a variant of mess in its sense of "to disorder." It was attested earlier (1830) as a noun meaning "disturbance, state of confusion." Related: Mussed; mussing.
the child mussed up my hair
Muskogean
muskrat
musky
Muslim
muslin
muss
mussel
Mussulman
mussy
must
mustache