"deny, make negative or null," 1795 (with an isolated use from 1620s), a back-formation from negation, or else from Latin negatus, past participle of negare, from PIE root *ne- "not." Related: Negated; negates; negating.
This action will negate the effect of my efforts
needy
neep
neese
nefandous
nefarious
negate
negation
negative
negativism
negativity
negatory